This is a great question I've asked myself, seen all the variables, and thought it wasn't easy. In airplanes, this stuff is calculated and is in the owners manual. Probably for helicopters too.
The wind direction will play into it. In a glider, there is a well known rule to get the best glide ratio: Fly at best glide speed in still air; fly best glide speed plus half the headwind speed, no matter how fast you end up having to go; best glide speed minus half the tailwind speed, but stop at the airspeed for "least sink rate", and go no slower.
Helicopters gain translational lift when moving forward, greatly reducing power requirements from a pure hover. I'm sure there is a best range speed/throttle combo that's published.
I assume a quad also gets translation lift while moving. How much power is being saved is hidden from us. A helicopter pilot will see he needs less throttle. Our left stick isn't "the pure throttle".
I'm not intimately friendly with the range/power status gadget at the top of the app. I need to RTFM again more carefully. But wouldn't that give an idea of optimal right stick position for best range, via changing its predictions, with different stick positions? I should know the answer. Sorry.
If full foward right stick gives maximum range (Big IF), then you'd use that for sure in a headwind, but whether to reduce right stick position in a tailwind is a function of things we don't know. How much power is saved, vs range lost.
If max range occurs at slightly less than full forward right stick in still air, then we could see best range with full right stick into a headwind, but save substantially backing off with a big tailwind. COOL QUESTION! Maybe I'll do a few experiments.