If your competent with basic PC upgrades, base a system off a reasonably up to date i7 processor. (Dual Xeon if you can stretch to it) couple this with at least 16gm Ram, a 1tb hard drive (72000rpm) and a good GPU (Nvidia gtx 9series), add a monitor.
Then as you can afford or see fit.. Upgrade ram to 32gb, get 1 or 2 SSD drives.
The processor/MB combo should be the best you can afford, with RAM & Gfx card second.. these are the heart of a power system, and will let you hit the ground running.. Th to find a MB that will take 64Gb off poss, this will help future-proof it. The other stuff (storage, peripherals) aren't as important but don't go too cheap or they will bottleneck your system.
Eventually, work up to a dual Xeon with 64gb, Titan or similar Gfx card and a bin load of hard drives set to raid stripe, with a juicy SSD at the front end to give you buffer & workspace. [emoji106] and don't forget the monitor. Consider a 48" UHD Tv as a cheaper alternative to a pro 4K monitor in the first instance as these can be pricey.
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