Once the mission starts, the orientation of the antennas is irrelevant as the mission will continue even if contact is lost. Make sure your "end action" is either RTH or back to the first waypoint.
Two things to be aware of:
If/when you get the scary message, "Warning! Disconnected!", don't panic. Don't hit the RTH button because it won't work anyway since you're disconnected. Do NOT flip to P mode (if by chance it reconnects, the mission will cancel and it will hover). Just wait. You'll have no telemetry telling you where your bird is. Your screen will be a static display with nothing changing. Just wait. Curse if you want to. Jump up and down. Cry like a schoolgirl. Then, just wait. The pucker factor will be very high. If you planned everything well, your bird will return. When you finally see/hear it and your video and telemetry flash back to life, you can stop sobbing and exclaim, "It worked! It $*%#ing worked! It's coming back! This is SO awesome!"
If at anytime during the mission you hear, "Mission Ended" (and you know it hasn't), don't touch anything. Don't DO anything. Just wait. All will be fine. This is due to an issue with the DJI SDK (Software Development Kit) that Litchi has no control over but it will not affect the flight and the mission has NOT ended far away from you. Just ignore it. I wrote Litchi about it because the first time it happened to me while my bird was far away, I came perilously close to soiling my Fruit of the Looms. They gave me the info above and told me it was safe to ignore.
Addendum: If you have your path set to straight lines instead of curved paths, the bird will stop briefly at each waypoint before continuing. This is only important because the calculated time of the mission will NOT include the additional time for this. The calculated time is based on continuous flight.
Addendum 2: Make sure your first and last waypoints are less than 2000 meters apart. If they're not, the mission won't load.
Good luck, happy flying and please reply back and let us know how it went. We expect a full journal, including all your feelings and emotional insights during this momentous occasion in your life. Ok, we'll settle for just a simple report.